- Humoral immunity
- Complement system, antobodies
- Cellular immunity
- T-Lymphocytes
- Stem cells of bone marrow ￫ red cells, leucocytes, B cells
- Thymus ￫ T cells
- Thymus
- Anterior mediastinum. Grows in childhood. Gradual involution after puberty. Continue to function during adult life.
- Immature T cells in cortex. Mature T cells in medulla
- Lymph nodes, Spleen, Mucosal-associated lymphoid tissue (MALT)
- Lymph nodes
- Comprise a cellular cortex
- Lymphocytes ￫ High endothelial venules ￫ Spleen, Lymph node
- B and T cells continue to recirculate through lymph node
- B cells
- B cells organised into follicles
- Active immune response ￫ B cells ￫ Follicles ￫ Germinal centres
- B cells ￫ Medulla ￫ Plasma cells ￫ Antibody
- T cells
- In deep cortex
- Antigen-presenting cells in B and T cells areas
- Spleen
- White pulp
- Organisation similar to B cell follicle and T cells areas
- Red pulp
- Blood vessels network removing old red blood cells
- MALT
- GIT: Peyer's patches in small intestine
- Respiratory tract: Tonsils. Adenoids
- Urogenital tract
- Bone marrow-derived
- For humoral antibody immune response
- Antigen ￫ B cells + T helper cells ￫ Immune response ￫ Immunoglobulin production IgM IgG
- Autoimmunity: Impaired mechanisms ￫ Self-reactive antibodies
T CELLS
- Recognise and discriminate antigens
- Receptors
- Antigen recognition: Petide fragments + HLA (human leucocyte antigen) molecules (clases I & II)
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