Impaired regulation of the immune response

CLONAL DISORDER

• Multiple myeloma
• Overproduction of specific monoclonal antibody
• Impaired function of the rest of hum oral immune system
• Paroxyamal nosturnal haemoglobinuria (PNH)
• Impaired production of molecules involved in contra of complement activation
• DAF
• CD59
• Complement ￫ RBC lysis ￫Haemolytic anaemia

AUTOIMMUNITY

• Impared regulation of humoral immunity ￫ Production of auto reactive antibodies (autoantibodies)
• vs: Receptors, DNA or othe intranuclear antigens, plasma proteins and macromolecules
• Autoreactive T lymphocytes also produced.