MRCP UK Revision
Granulomatosis with polyangiitis (GPA)
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Granulomatosis with polyangiitis (GPA, previously known as Wegener's disease) is an autoimmune multisystem disorder of unknown aetiolog...
Diagnosis of Systemic Lupus Erythematosus (SLE)
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The diagnosis is SLE: •Raynaud’s phenomenon, myalgia and arthralgia •Painless mouth ulcers •The scalp lesion described is discoid lupus •Leu...
Cardiac amyloidosis
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The commonest cause of death in amyloidosis is secondary to cardiac involvement. It may present with the insidious onset of vague symptoms,...
Klinefelter’s syndrome
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Klinefelter’s syndrome, which not uncommonly presents in adult life rather than at adolescence. This syndrome is characterised by dysgenes...
Oncogenes
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Initially identified as viral gene Proto-oncogenes Genes within normal DNA of every cell Mutated, activated → Product → Tumour In...
Metformin
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Metformin is a useful first-line treatment for diabetes and would be particularly appropriate in this overweight patient as it was the only ...
Sulphonylureas
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Sulphonylureas promote weight gain as demonstrated in the UKPDS study
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