BASIC PRINCIPLES OF CELL-CELL SIGNALLING
- Generator cell produces a chemical signal (or ligand)
- Ligand binds with receptors
- Initiation of intracellular events.
- Intracellular messenger
- Limited receptors. Specific response.
- Dual function of receptors
- Ligand binding
- Signal transduction
- Patterns of intracellular communication
- Endocrine
- Specialised cells
- Hormone
- Circulate in bloodstream
- Distant target cells
- Integrating ad harmonising responses in disparate cells and tissues
- Growth. Puberty. Pregnacy
- Paracrine
- Ligand
- Diffuses locally
- Adjacent cells
- Within organs or tissues
- Tubuloglomerular feedback in kidney
- Synaptic
- Interneuronal or neuromuscular synaptic transmission
- Close physical proximity of generator and target cells
CYTOSOLIC RECEPTORS
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