- Steroids ￫ Cytosolic receptors ￫ Modify gene transcription
- Lipid soluble ligand + Receptor ￫ Dimerisation ￫ Translocation of ligand-receptor complex into nucleus ￫ Specific binding of complex to promoter or enhancer elements of genes ￫ Modulation of gene transcription.
- Receptor monomers
- Ligand-binding domain. Highly homologous domains.
- DNA binding. Transciption activation
- De novo gene transcription & protein synthesis
- Slow onset. Long lasting
Cytosolic receptors
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