Priming of naïve T cells in renal transplant

Priming of naïve T cells is carried out in local lymph nodes by professional antigen presenting cells such as dendritic cells. In the case of a renal transplant this may occur by T cells recognising donor MHC on donor dendritic cells transferred with the graft (direct pathway). It may also occur by the recognition of peptides derived from donor MHC molecules, presented on recipient MHC on recipient antigen presenting cells (indirect pathway).