HLA B27

HLA B27 is associated with seronegative spondyloathropathy including:

  • Ankylosing spondylitis
  • Reiter’s syndrome
  • Spondyloarthropathy of inflammatory bowel disease
  • Psoriasis
  • Juvenile chronic arthritis (juvenile spondyloarthropathy).

HLA-B27 is found in approximately 50% of patients who have uveitis in the absence of rheumatic disease.

Behcet’s disease is associated with high prevalence of HLA B5.

Reference

  • Savolainen HA, Lehtimaki M, Kautiainen H, Aho K, Anttila P. HLA B27: a prognostic factor in juvenile chronic arthritis. Clin Rheumatol 1998; 17(2): 121-4.
  • Gonzalez S, Martinez-Borra J, Lopez-Larrea C. Immunogenetics, HLA-B27 and spondylarthropathies. Curr Opin Rheumatol 1999; 11: 257 264.
  • Huhtinen M, Karma A. HLA-B27 typing in the categorisation of uveitis in a HLA-B27 rich population. Br J Ophthalmol 2000; 84(4): 413-6.
  • Gul A, Hajeer AH, Worthington J, Barrett JH, Ollier WE, Silman AJ. Evidence for linkage of the HLA-B locus in Behcet’s disease, obtained using the transmission disequilibrium test. Arthritis Rheum 2001; 44(1): 239-40.

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