Nebulised recombinant DNase use in cystic fibrosis

Nebulised recombinant DNase can enhance sputum clearance and improve lung function, but it is expensive and its benefit should be assessed in each individual patient. Regular inhaled corticosteroids may be helpful in cystic fibrosis but oral steroids should be avoided. Long term use of macrolide antibiotics such as azithromycin, or nebulised antibiotics such as colomycin or tobramycin, may reduce the frequency of exacerbations.