In anaphylaxis, a treatment with intramuscular epinephrine (0.5 ml of 1/1000) is required.
In extremis, epinephrine can be given intravenously, but at reduced dosage: make a 1/10,000 solution (by diluting 1 ml of 1/1000 to 10 ml with 0.9% saline) and give this at 1 ml/min (0.1 mg/min) until a response has been obtained (or a total of 0.5 mg - 5 ml - has been given).
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