Anti-HIV drugs are associated with numerous side effects but are not linked to hypocalcaemia.
Some data, however, do suggest a link with premature osteoporosis.
Facial thinning is caused by fat redistribution (lipodystrophy) associated with insulin resistance, and disturbed fat and glucose metabolism.
Zidovudine induces a grey discolouration of the nails in persons with pigmented skins. Indinavir crystallises in the renal tract leading to renal impairment and stones.
One of the most serious side effects is lactic acidosis and liver failure associated with nucleoside reverse transcriptase inhibitors.
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