- Initially identified as viral gene
- Proto-oncogenes
- Genes within normal DNA of every cell
- Mutated, activated ￫ Product ￫ Tumour
- Influence is direct or indirect
- e.g. mitogen-activated protein kinase (MAPK) pathway
- Amino acid substitutions @ 21 or 61 in Ras
- Activating ERK MAPK pathway
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