Memory T cells are generated after a primary immune response and allow a more rapid response when the same antigen is subsequently encountered. Cell surface markers characterising memory cells include CD45RO+ and CD44high.
The situation is becoming increasingly complex due to the recognition of several layers of T cell heterogeneity. The chemokine receptor CCR7 has been shown to further divide memory T cells into true memory cells (CCR7+) and 'effector' memory cells (CCR7-), with the latter circulating through peripheral tissues, and the former through lymphoid tissue.
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