Drug-induced acute interstitial nephritis

The drugs that most commonly cause acute interstitial nephritis are penicillins, non-steroidal anti-inflammatory drugs and thiazide diuretics.

When the circulation is compromised, non-steroidal anti-inflammatory agents, angiotensin converting enzyme inhibitors (such as enalapril) and angiotensin-II receptor antagonists (such as candesartan) can have adverse haemodynamic effects on the kidney leading to a reduction in GFR, but ACE inhibitors and AT2 blockers are not associated with interstitial nephritis.